Adopting a humorous view towards life's situations can take the edge off everyday stressors. Not being too serious or in a constant alert mode helps maintain the equanimity of mind and promote clear thinking.Being able to laugh stress away is the smartest way to ward off its effects.A sense of humor also allows us to perceive and appreciate the incongruities of life and provides moments of delight. The emotions we experience directly affect our immune system. The positive emotions can create neurochemical changes that buffer the immunosuppressive effects of stress.During stress, the adrenal gland releases corticosteroids, which are converted to cortisol in the blood stream. These have an immunosuppressive effect. Dr. Lee Berk and fellow researcher Dr. Stanley Tan at Loma Linda University School of Medicine have produced carefully controlled studies showing that the experience of laughter lowers serum cortisol levels, increases the amount and activity of T lymphocytes—the natural killer cells. Laughter also increases the number of T cells that have suppresser receptors.